Haematology
The Clinical Haematology Service based at the Royal Hallamshire Hospital offers a comprehensive service to provide diagnosis and treatment for haematological disorders of both malignant and non-malignant, and provides an on-site diagnostic service and continuing management for patients.
Specialist treatments available include red cell exchange, chemotherapy, administration of coagulation factors, bone marrow transplant, chimeric antigen receptor T-cell (CAR T-cell) therapy and the collection, storage and transplantation of bone marrow and blood stem cells.
The Department is a regional specialist centre for stem cell transplant and has received internationally recognised accreditation for the adult stem cell transplant programme by JACIE, which provides a comprehensive service for the treatment of cancer and some autoimmune conditions (MS,SS) . We offer high-dose therapy with bone marrow and peripheral blood stem-cell support, plus an outpatient department with dedicated day-case facilities for the treatment of patients undergoing transfusion. Cell collection and plasma exchange are performed in a dedicated Apheresis unit on Ward O2.
Our clinicians are highly experienced in their fields of haematology, with particular expertise in the assessment, investigation and treatment for a range of blood diseases, including:
• Blood cancers
• Acute myeloid (AML) and Acute Lymphoblastic Leukaemia (ALL)
• Chronic myeloid leukaemia (CML)
• Chronic lymphocytic leukaemia (CLL)
• Lymphoma
• Myelodysplastic syndrome (MDS)
• Myeloma (MM)
• Myeloproliferative disorders (MPD)
• Benign blood conditions
• Anaemia
• Disorders of clotting (thrombophilia)
• Haemophilia and associated disorders
• Immune thrombocytoenia purpura (ITP)
• Sickle cell disease and thalassemia
• Thrombotic Thrombocytopenic Purpura (TTP)
• Aplastic anaemia
We also provide a wide range of services for our patients, including day care treatment, inpatient wards, outpatient clinics, clinical nurse specialist support, and pregnancy care (provided jointly with the maternity at the Jessops Hospital). We also offer care and treatment for patients with more rare immune haematological disorders including thrombotic thrombocytopenia (TTP), autoimmune haemolytic anaemia (AIHA) and haemophagocytic lymphohistiocytosis (HLH).
In addition to our outpatient services we have three inpatient services comprising of 3 wards, all based at the Royal Hallamshire Hospital, P3 and P4 and O1 with 47 beds dedicated to the management of haematology patients. These include 29 side rooms, 12 of which are HEPA filtered for all levels of Haematopoietic Stem Cell Transplantation and Leukemic induction therapy.
Our Late Effects Service has long been developed as a collaboration between adult haematology and paediatric haematology/oncology services, Endocrinology, Reproductive Medicine and Psychiatry, and has an international academic reputation which is based at the Royal Hallamshire Hospital and Weston Park Hospital caring for people living with and beyond cancer.
We also have a dedicated day case facility, an Apheresis Unit (managed by the NHSBT) and the Centre for Haemophilia and Thrombosis. A significant amount of chemotherapy of all intensities is administered to out-patients on the Day Ward, as are the majority of blood transfusions, venesections, and early follow-up of BMT patients is conducted. Following a pilot project funded by the Health Foundation, ambulatory care (based either at home or from dedicated patient flats) is offered to clinically eligible patients undergoing myeloma and lymphoma autografts, lymphoma salvage chemotherapy and AML consolidation chemotherapy. We have commenced delivery of Ambulatory Reduced Intensity conditioning for allogeneic stem transplants in selected cases and plan to further expand our Ambulatory Programme.
Our dedicated Haemato-oncology clinical trials team are an integral part of our clinical service. The clinical trial work of the team sits within The Academic Directorate of Communicable Diseases and Specialised Medicine (CDSM). Our purpose-built clinical research facility (CRF) provides an ideal environment, with consulting rooms, treatment suite and sample processing laboratory, for the assessment and treatment of patients on novel therapies.
