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Dr Andreas Kyriacou

  • Consultant Cardiologist and Electrophysiologist


Consultant Cardiologist and Electrophysiologist
Honorary Senior Clinical Lecturer, Sheffield University

Specialist Clinical Interests

Medical treatment and ablation of heart rhythm disorders including complex arrhythmias such as atrial fibrillation and ventricular tachycardia.
Implantation of complex cardiac pacemakers and defibrillators.

Research Interests

Investigating the effects of complex cardiac pacing on heart function and coronary artery physiology.
Maximizing the benefits derived from cardiac pacemakers and cardiac resynchronisation therapy.

Professional Profile


I graduated from the University of Edinburgh in 2001. I trained in Cardiology and subspecialised in Cardiac arrhythmias in London. I worked at St Marys and Hammersmith Hospitals of Imperial College Healthcare NHS Trust, where I also carried out research (a 3 year clinical research training fellowship funded by the BHF) in complex cardiac pacemakers. I explored the physiological effects of complex pacing on heart function and developed methods to improve patient outcomes. This work led to a number of publications and was recognised by the European Society of Cardiology Heart Failure Association (Young Investigator in Clinical Research – Winner, 2012) and the British Heart Rhythm Society (Young Investigator Competition – Runner up, 2012).

I concluded my training in cardiac arrhythmias at the Royal Brompton and Harefield Hospitals where I focused on the ablation of complex arrhythmias including atrial fibrillation and ventricular tachycardias.

In 2015, I was appointed to the post of Consultant Cardiologist and Electrophysiologist at Sheffield Teaching Hospitals NHS Foundation Trust.


Education and Training

2013 International Board of Heart Rhythm Examiners (IBHRE), Certified Cardiac
Device Specialist (CCDS)
2009 - 2012 Clinical Research Training Fellowship, British Heart Foundation.
2008 – 2011 Doctor of Philosophy, National Heart and Lung Institute, Imperial College
London, UK
2007 – 2015 Academic Clinical National Training Number in Cardiology (Walport NIHR
Fellowship), NW Thames, London, 2007 – 2015
2004 MRCP, Royal College of Physicians, London
1996 – 2001 MBChB, Faculty of Medicine, University of Edinburgh

Current membership(s) of professional, national and regional bodies and university posts

Member of the Royal college of Physicians
British Heart Rhythm Society
Medical Protection Society
British Medical Association


1. Kyriacou A, Hayat S, Qureshi N, Peters NS, Kanagaratnam P, Lim PB. Dissociated pulmonary vein potentials: Expression of the cardiac autonomic nervous system following pulmonary vein isolation? Heart Rhythm Case Rep. 2015 Sep 4;1(6):401-405

2. Sohaib SM, Kyriacou A, Jones S, Manisty CH, Mayet J, Kanagaratnam P, Peters NS, Hughes AD, Whinnett ZI, Francis DP. Evidence that conflict regarding size of haemodynamic response to interventricular delay optimization of cardiac resynchronization therapy may arise from differences in how atrioventricular delay is kept constant. Europace. 2015 Dec;17(12):1823-33

3. Finegold J, Bordachar P, Kyriacou A, Sohaib SM, Kanagaratnam P, Ploux S, Lim B, Peters N, Davies W, Ritter P, Francis DP, Whinnett ZI. Atrioventricular delay optimization of cardiac resynchronisation therapy: Comparison of non-invasive blood pressure with invasive haemodynamic measures. Int J Cardiol. 2015 Feb 1;180:221-2

4. Baruah R, Giannoni A, Willson K, Manisty CH, Mebrate Y, Kyriacou A, Yadav H, Unsworth B, Sutton R, Mayet J, Hughes AD, Francis DP. Novel cardiac pacemaker-based human model of periodic breathing to develop real-time, pre-emptive technology for carbon dioxide stabilisation. Open Heart. 2014 Aug 12;1(1):e000055

5. Kyriacou A, Pabari PA, Mayet J, Lefroy D, Davies DW, Peters NS, Lim PB, Kanagaratnam P, Hughes AD, Francis DP, Whinnett ZI. Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally. Int J Cardiol. 2014 Feb 1;171(2):144-52.

6. Whinnett ZI, Sohaib SM, Jones S, Kyriacou A, March K, Coady E, Mayet J, Hughes AD, Frenneaux M, Francis DP. British randomised controlled trial of AV and VV optimization ("BRAVO") study: rationale, design, and endpoints. BMC Cardiovasc Disord. 2014 Apr 3;14(1):42

7. Jamil-Copley S, Bokan R, Kojodjojo P, Qureshi N, Koa-Wing M, Hayat S, Kyriacou A, Sandler B, Sohaib A, Wright I, Davies DW, Whinnett Z, S Peters N, Kanagaratnam P, Lim PB. Noninvasive electrocardiographic mapping to guide ablation of outflow tract ventricular arrhythmias. Heart Rhythm. 2014 Apr;11(4):587-94

8. Jones S, Shun-Shin MJ, Cole GD, Sau A, March K, Williams S, Kyriacou A, Hughes AD, Mayet J, Frenneaux M, Manisty CH, Whinnett ZI, Francis DP. Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines. Europace. 2014 Apr;16(4):541-50

9. Raphael CE, Kyriacou A, Jones S, Pabari P, Cole G, Baruah R, Hughes AD, Francis DP. Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT. Int J Cardiol. 2013 Sep 20;168(1):407-13

10. Kyriacou A, Li Kam Wa ME, Pabari PA, Unsworth B, Baruah R, Willson K, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DP. A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy. Int J Cardiol. 2013 Aug 10;167(3):954-64

11. Kyriacou A, Whinnett ZI, Sen S, Pabari PA, Wright I, Cornelussen R, Lefroy D, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JE. Improvement in Coronary Blood Flow Velocity with Acute Biventricular Pacing is Predominantly Due to an Increase in a Diastolic Backward-Travelling Decompression (Suction) Wave. Circulation. 2012 Sep 11;126(11):1334-44

12. Kyriacou A, Pabari PA, Whinnett ZI, Arri S, Willson K, Baruah R, Stegenmann B, Mayet J, Kanagaratnam P, Hughes AD, Francis DP. Fully automatable, reproducible, noninvasive simple plethysmographic optimization: proof of concept and potential for implantability. Pacing Clin Electrophysiol. 2012 Aug;35(8):948-60

13. Kyriacou A, Pabari PA, Francis DP. Cardiac resynchronization therapy is certainly cardiac therapy, but how much resynchronization and how much atrioventricular delay optimization? Heart Fail Rev. 2012 Nov;17(6):727-36

14. Pabari PA, Willson K, Stegemann B, van Geldorp IE, Kyriacou A, Moraldo M, Mayet J, Hughes AD, Francis DP. When is an optimization not an optimization? Evaluation of clinical implications of information content (signal-to-noise ratio) in optimization of cardiac resynchronization therapy, and how to measure and maximize it. Heart Fail Rev. 2011 May;16(3):277-90

15. Unsworth B, Casula RP, Kyriacou A, Yadav H, Chukwuemeka A, Cherian A, Stanbridge Rde L, Athanasiou T, Mayet J, Francis DP. The right ventricular annular velocity reduction caused by coronary artery bypass graft surgery occurs at the moment of pericardial incision. Am Heart J. 2010 Feb;159(2):314-22

16. Yadav H, Unsworth B, Fontana M, Diller GP, Kyriacou A, Baruah R, Mayet J, Francis DP. Selective right ventricular impairment following coronary artery bypass graft surgery. Eur J Cardiothorac Surg. 2010 Feb;37(2):393-8

17. Diller GP, Wasan BS, Kyriacou A, Patel N, Casula RP, Athanasiou T, Francis DP, Mayet J. Effect of coronary artery bypass surgery on myocardial function as assessed by tissue Doppler echocardiography. Eur J Cardiothorac Surg. 2008 Nov;34(5):995-9


Additional Information

Contact details

Telephone Number: 0114 3052303


Name: Cardiac Rhythm Management Secretaries, Second Floor, Chesterman Wing, Northern General Hospital.

Telephone: 0114 2715379



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