Research

UK-PBC - A research consortium undertaking several projects in the management of PBC
REDUCE-2 – Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatabke Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial
REACT-AVB – Randomised controlled trial of early transjugular intrahepatic portosystemic stent-shunt in acute variceal bleeding
NATiV3 - randomised, double-blind, placebo-controlled, multicentre, Phase 3 study evaluating efficacy and safety of lanifibranor followed by an active treatment extension in adult patients with non-cirrhotic non-alcoholic steatohepatitis (NASH) and fibrosis 2 (F2)/fibrosis 3 (F3) stage of liver fibrosis
Polycystic Liver Disease registry – International registry
Asp-PSC - Effect of Aspirin on Reducing Cancer & Improving Outcomes in Primary Sclerosing Cholangitis (PSC)
ALLHEAL – Alcohol and liver health - a prospective database of individuals with all stages of alcohol related liver disease (ArLD), including people at risk of ArLD (i.e. people who drink hazardously) but who have not yet developed overt liver disease.
Alcochange – Real world implementation of AlcoChange: a smartphone digital therapeutic to improve outcomes from alcohol-related liver disease
PEARL: Prospective Cohort for the Early Detection of Liver Cancer (met recruitment target)

FARGO - A randomised, phase IIa, multi-centre, placebo-controlled trial of faecal microbiota transplantation in primary sclerosing cholangitis
AFFIRM – A randomised, double-blind, placebo-controlled, study to evaluate the effect of Seladelpar on clinical outcomes in patients with primary biliary cholangitis and compensated cirrhosis
A-TANGO - Phase 2, double-blind, randomized, placebo-controlled, multicentre study to evaluation the safety, efficacy, and pharmacokinetics of TAK-242 and Granulocyte Colony-Stimulating Factor (G-CSF) (G-TAK) in subjects with severe alcoholic hepatitis (sAH) and acute-on-chronic liver failure (ACLF)