The Genomics of Exercise

Physical exercise and rehabilitation programmes improve survival in ACS patients reduce symptoms of angina. The growth of collateral blood vessels in the heart is dependent upon the presence of recruited blood monocytic cells.

Using bioinformatic approaches outlined above, Dr Chico is being supported with a protocol examining the peripheral blood white cell gene expression in the context of exercise training.

REC approval has been granted for a study examining the effect of exercise training on peripheral blood gene expression in patients with angina, in collaboration with Professor John Saxton from UEA. Supervised exercise-based training will be performed at the Centre for Sports and Exercise Science at Sheffield Hallam University by a post-doc, Liam Bourke. This is part funded by the Cardiothoracic Directorate FSF.