Our laboratory is staffed by skilled, experienced laboratory personnel who carry out the analysis for the clinical trials run by the Bone BRU.
We also frequently collaborate with other departments within the University and with external institutions and industry and also provide a BTM assay service.
We give advice on the most appropriate marker(s), on the collection and storage of samples and on the interpretation of results.
Bone turnover markers premenopausal reference intervals
This reference range is based on a healthy premenopausal population aged between 35 and 45 years. (N = 153)
Manual ELISA’s
| Geometric mean | Lower | Upper | |
| Intact PTH pg/ml (Biomerica) | 69.9 | 31.9 | 153.1 |
| CTX ng/ml (IDS) | 0.43 | 0.20 | 0.88 |
| Intact PINP µg/L (Orion RIA) | 33.1 | 18.1 | 60.4 |
| Osteocalcin ng/ml (Nordic) | 14.8 | 7.3 | 30.2 |
| TRAP 5b IU/L (Nittibo, Japan) | 1.76 | 0.85 | 3.66 |
Roche Diagnostics COBAS E411
| Geometric mean | Lower | Upper | |
| Intact PTH pg/ml | 36.6 | 18.2 | 73.8 |
| CTX ng/ml | 0.20 | 0.09 | 0.63 |
| Intact PINP ng/ml | 32.3 | 18.3 | 56.9 |
| Osteocalcin ng/ml | 16.9 | 9.1 | 31.6 |
Access II Bone ALP (OSTASE)
| Geometric mean | Lower | Upper | |
| Bone ALP µg/L | 9.5 | 5.7 | 17.3 |
Vitros (Ortho Clinical Diagnostics)
| Geometric mean | Lower | Upper | |
| uNTX nmol BCE/mmol Cr | 27.9 | 13.9 | 55.9 |
