Professor Richard Eastell

MD FRCP FRCPI FRCPEdin FRCPath FMedSci

Professor of Bone Metabolism and Director of the NIHR Biomedical Research Unit for Musculoskeletal Disease

 

 Research Interests

• Defining vertebral fractures
• Clinical utility of bone turnover markers
• Clinical utility of ultrasound measurements of bone
• Pathogenesis of postmenopausal osteoporosis
• Pathogenesis of male osteoporosis
• Orthopaedic applications of bone densitometry
• Treatment of postmenopausal osteoporosis
 

External Positions

• Past President of the Bone Research Society
• Past President of the European Calcified Tissue Society and Scientific Chairman of the Programme Committee for the 2009 ECTS meeting (Vienna)
• Past Chairman of National Osteoporosis Society
• Medical and Scientific Board of the National Osteoporosis Society
• Medical Research Council and NIHR Efficacy and Mechanism Evaluation Board
• Editorial board of Osteoporosis International, Osteoporosis Review, and Bone (Associate Editor)

Journal reviewer for American Journal of Obstetrics and Gynaecology, Bone, British Medical Journal, Calcified Tissue International, Clinical Chemistry, Clinical Science, Clinical Endocrinology, Drug and Therapeutics Bulletin, Journal of Bone and Mineral Research, Journal of Clinical Endocrinology & Metabolism, Journal of Clinical Densitometry, Journal of Clinical Investigation, Journal of Internal Medicine, Lancet, New England Journal of Medicine, Osteoporosis International, Quarterly Journal of Medicine, Rheumatology.

Invited Lectures

• American Society for Bone and Mineral Research, 2007 and 2010 (debate)
• British Endocrine Society, 2009, 2010 
• European Calcified Tissue Society, 2008
• European League Against Rheumatism 2008 and 2009
• International Bone and Mineral Society, 2007
• The Endocrine Society, 2007
 

Recent Awards

Senior Investigator Award, National Institutes of Health Research (2009)
Linda Edwards Memorial Lecturer for the National Osteoporosis Society (2006)
PathWest Visiting lecturer in Perth, Australia (2005)
Society for Endocrinology Medal (2004)
Kohn Award from the National Osteoporosis Society (2004)

Key Publications

I have published 100 articles in the last 5 years; 95 in peer-reviewed journals.

Cummings SR, Ensrud K, Delmas PD, LaCroix AZ, Vukicevic S, Reid DM, Goldstein S, Sriram U, Lee A, Thompson J, Armstrong RA, Thompson DD, Powles T, Zanchetta J, Kendler D, Neven P, Eastell R; PEARL Study Investigators. (2010) Lasofoxifene in postmenopausal women with osteoporosis. N Engl J Med. 362(8):686-96 Abstract

Black DM, Kelly MP, Genant HK, Palermo L, Eastell R, Bucci-Rechtweg C, Cauley J, Leung PC, Boonen S, Santora A, de Papp A, Bauer DC; Fracture Intervention Trial Steering Committee; HORIZON Pivotal Fracture Trial Steering Committee. (2010) Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med. 362(19):1761-71 Abstract

Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; FREEDOM Trial. (2009)  Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 361(8):756-65 Abstract

Rogers A, Glover SJ, Eastell R. (2009) A randomised, double-blinded, placebo-controlled, trial to determine the individual response in bone turnover markers to lasofoxifene therapy. Bone. 45(6):1044-52 Abstract

Delmas PD, Munoz F, Black DM, Cosman F, Boonen S, Watts NB, Kendler D, Eriksen EF, Mesenbrink PG, Eastell R; HORIZON-PFT Research Group. (2009) Effects of yearly zoledronic acid 5 mg on bone turnover markers and relation of PINP with fracture reduction in postmenopausal women with osteoporosis. J Bone Miner Res. 24(9):1544-51 Abstract

Eastell R, Nickelsen T, Marin F, Barker C, Hadji P, Farrerons J, Audran M, Boonen S, Brixen K, Gomes JM, Obermayer-Pietsch B, Avramidis A, Sigurdsson G, Glüer CC. (2009) Sequential treatment of severe postmenopausal osteoporosis after teriparatide: final results of the randomized, controlled European Study of Forsteo (EUROFORS). J Bone Miner Res. 24(4):726-36 Abstract

Yang L, Peel N, Clowes JA, McCloskey EV, Eastell R. (2009) Use of DXA-based structural engineering models of the proximal femur to discriminate hip fracture. J Bone Miner Res.  24(1):33-42 Abstract

Cummings SR, Ettinger B, Delmas PD, Kenemans P, Stathopoulos VVerweij P, Mol-Arts M, Kloosterboer L, Mosca L, Christiansen C, Bilezikian J, Kerzberg EM, Johnson S, Zanchetta J, Grobbee DE, Seifert W, Eastell R; LIFT Trial Investigators. (2008) The effects of tibolone in older postmenopausal women. N Engl J Med. 359(7):697-708 Abstract

Eastell R, Adams JE, Coleman RE, Howell A, Hannon RA, Cuzick J, Mackey JR, Beckmann MW, Clack G. (2008) Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230. J Clin Oncol. 26(7):1051-7 Abstract

Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC, Man Z, Mautalen C, Mesenbrink P, Hu H, Caminis J, Tong K, Rosario-Jansen T, Krasnow J, Hue TF, Sellmeyer D, Eriksen EF, Cummings SR; HORIZON Pivotal Fracture Trial. (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 356(18):1809-22 Abstract

Key Reviews

Eastell R, Newman C, Crossman DC. (2010) Cardiovascular disease and bone. Arch Biochem Biophys. 503(1):78-83 Abstract

Eastell R, Arnold A, Brandi ML, Brown EM, D'Amour P, Hanley DA, Rao DS, Rubin MR, Goltzman D, Silverberg SJ, Marx SJ, Peacock M, Mosekilde L, Bouillon R, Lewiecki EM. (2009) Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab. 94(2):340-50 Abstract

Reid DM, Doughty J, Eastell R, Heys SD, Howell A, McCloskey EV, Powles T, Selby P, Coleman RE. (2008) Guidance for the management of breast cancer treatment-induced bone loss: a consensus position statement from a UK Expert Group. Cancer Treat Rev. 34 Suppl 1:S3-18 Abstract

Eastell R, Hannon RA. (2008) Biomarkers of bone health and osteoporosis risk. Proc Nutr Soc. 67(2):157-62 Abstract

Eastell R. (2007)  Breast cancer and the risk of osteoporotic fracture: A paradox. J Clin Endocrinol Metab. 92(1):42-3 Abstract