Mr Mark Wilkinson

MB ChB, PhD, FRCS (Orth)

Clinical Senior Lecturer in Orthopaedics, University of Sheffield; Honorary Consultant Orthopaedic Surgeon, Sheffield Teaching Hospitals NHS Foundation Trust

Research interests

• Genetics and metabolic aspects of arthritis and bone responses to joint replacement
• Use of bisphosphonates to suppress bone loss after hip replacement
• Identification of novel biomarkers and imaging techniques for detecting osteolysis
• Exploration of the molecular mechanisms in osteolysis
• Novel pharmacological strategies for treatment of osteolysis
• Systemic health effects of metal ion exposure following hip resurfacing
• Joint arthroplasty mechanisms of failure
• Cytokine genetics
• Metabolic bone disease
• Surrogate outcome markers for implant performance and failure
• Clinical outcomes measurement after total hip arthroplasty (THA)
 

Trust and University positions

• Chair of the steering committee for the Sheffield Musculoskeletal Biobank
• UoS Mellanby Centre Management group
• STHFT Clinical Research Facility Scientific Advisory Board
• STHFT – UoS Human Tissue Act Committee
• STHFT Biorepository Committee
• UoS - Faculty of Medicine Research Meeting Working Group
• Deputy director of the Sheffield NIHR Bone Biomedical Research Unit
• STHFT NIHR Bone BRU management committee

External postions

• Arthritis Research UK Research sub-committee
• Arthritis Research UK Patient and Public Publications Advisory Group - Expert advisory pane 
• Arthritis Research UK Clinical Studies Steering Group (metabolic bone disease) Committee
• Board of Directors of the Orthopaedic Research Society (USA)
• Special Projects Committee Chair for the Orthopaedic Research Society (USA)
• Annual Meeting Committee of the Orthopaedic Research Society (USA)
• Professional Development and Mentoring Council of the Orthopaedic Research Society (USA)
• Research Committee of the British Orthopaedic Association
• Sheffield Research Ethics Committee Expert Panel
• arcOGEN consortium, genetics of osteoarthritis Steering Committee
• Editorial board (orthopaedics editor) of Surgery Journal.
 

Grant Reviewer for Academy of Medical Sciences, Wellcome Trust, Arthritis Research UK, Dutch Arthritis Association, National Institutes of Health RfPB programme, Medical Research Council, NHS Grampian

Journal reviewer for Age and Ageing, Arthritis and Rheumatism, Bone, Clinical Biomechanics, Clinical Chemistry, Clinical Orthopaedics and Related Research, Calcified Tissue International, Cytokine, Expert Review of Clinical Devices, Journal of Bone and Mineral Research, Journal of Orthopaedic Research, Journal of the Royal College of Surgeons of England, Maturitas, Molecular Biology Reports, Osteoarthritis and Cartilage, Rheumatology.

Key Publications

Evangelou V, Valdes AM, Kerkhof HJM, Styrkarsdottir U, Zhu YY, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD, arcOGEN consortium, Akune T, Arden NK, Carr AJ, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WER, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Slagboom PE, Sudo A, A Tamm, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JPA, Spector TD. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (in press)

Emms NW, Stockley I, Hamer AJ, Wilkinson JM. (2010) Long-term outcome of a cementless, hemispherical, press-fit acetabular component: survivorship analysis and dose-response relationship to linear polyethylene wear. J Bone Joint Surg Br. 92(6):856-61 Abstract 

Gordon A, Greenfield EM, Eastell R, Kiss-Toth E, Wilkinson JM. (2010) Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli. J Orthop Res. 28(9):1127-35 Abstract

Gordon A, Kiss-Toth E, Stockley I, Eastell R, Wilkinson JM. (2008) Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. Arthritis Rheum. 58(10):3157-65 Abstract

Gordon A, Southam L, Loughlin J, Wilson AG, Stockley I, Hamer AJ, Eastell R, Wilkinson JM. (2007) Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty. J Orthop Res. 25(12):1665-70 Abstract  

Shetty NR, Hamer AJ, Kerry RM, Stockley I, Eastell R, Wilkinson JM. (2006) Bone remodelling around a cemented polyethylene cup: A longitudinal densitometry study. J Bone Joint Surg Br. 88(4):455-9 Abstract

Ali F, Wilkinson JM, Cooper JR, Kerry RM, Hamer AJ, Norman P, Stockley I. (2006) The accuracy of hip joint aspiration for the pre-operative diagnosis of infection in total hip arthroplasty. J Arthroplasty. 21(2):221-6 Abstract

Wilkinson JM, Hamer AJ, Stockley I, Eastell R. (2005) Polyethylene wear and osteolysis: Critical threshold versus continuous dose-response relationship. J Orthop Res. 23(3):520-5 Abstract

Wilkinson JM, Eagleton AC, Stockley I, Peel NFA, Hamer AJ, Eastell R. (2005) Effect of pamidronate on bone turnover and implant migration after total hip arthroplasty: A randomized trial. J Orthop Res. 23(1):1-8 Abstract

Wilkinson JM, Wilson AG, Gordon A, Stockley I, Scott IR, Macdonald DA, Hamer AJ, Duff GW, Eastell R.(2003) Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty. J Bone Miner Res. 18(11):1995-2001 Abstract