Professor Eugene McCloskey
MB BCh BAO MD MRCP
Professor of Adult Bone Disease, University of Sheffield; Honorary Consultant Physician in Metabolic Bone Disease, NIHR Biomedical Research Unit for Musculoskeletal Disease, Sheffield Teaching Hospitals NHS Trust
Research interests
• Interactions between pharmacological and physical osteoporosis therapies
• Fracture risk assessment
• The development and refinement of the WHO Fracture Risk Algorithm (FRAX®)
http://www.sheffield.ac.uk/FRAX/
• Epidemiology and definition of vertebral fractures
• Techniques in the diagnosis and management of osteoporosis
• Benign and malignant bone disease
• Bisphosphonates as inhibitors of bone complications and metastatic bone disease
Academic responsibilities
• Co-ordinates undergraduate musculoskeletal teaching
External Positions
• Lead of Musculoskeletal Priority Group, South Yorkshire Comprehensive Local Research Network
• Chair of the National Osteoporosis Guidance Group Implementation Committee for FRAX
• Chair of the ASBMR Research Ancillary Programme Committee
• Secretary for Bone Research Society Board
• National Osteoporosis Society Scientific Advisory Board
• International Osteoporosis Foundation’s Committee of Scientific Advisors
• Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis
• ICUROS project manager for the UK
Key Publications
Gauthier A, Kanis JA, Martin M, Compston J, Borgström F, Cooper C, McCloskey EV. On behalf of the Committee of Scientific Advisors, International Osteoporosis Foundation. Development and validation of a disease model for postmenopausal osteoporosis, Osteoporos Int. 2010 Aug 11. [Epub ahead of print] Abstract
Johansson H, Odén A, Kanis J, McCloskey EV, Lorentzon M, Ljunggren O, Karlsson MK, Orwoll E, Tivesten A, Ohlsson C, Mellström D. Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden. Osteoporos Int. 2010 Jun 29. [Epub ahead of print] Abstract
Leslie WD, Lix LM, Johansson H, Oden A, McCloskey EV, Kanis JA. Manitoba Bone Density Program. Independent clinical validation of a Canadian FRAX((R)) tool: Fracture prediction and model calibration. J Bone Miner Res. 2010 Apr 30. [Epub ahead of print] Abstract
Borgström F, Ström O, Kleman M, McCloskey EV, Johansson H, Odén A, Kanis JA. (2010) Cost-effectiveness of bazedoxifene incorporating the FRAX(R) algorithm in a European perspective. Osteoporos Int. 21(3):495-505 Abstract
Kanis JA, McCloskey EV, Johansson H, Oden A, Ström O, Borgström F. (2010) Development and use of FRAX in osteoporosis. Osteoporos Int. Suppl 2:S407-13. Abstract
Kanis JA, Johansson H, Oden A, McCloskey EV. (2010) A meta-analysis of the efficacy of raloxifene on all clinical and vertebral fractures and its dependency on FRAX. Bone. 47(4):729-35 Abstract
Kayan K, Johansson H, Oden A, Vasireddy S, Pande K, Orgee J, Kanis JA, McCloskey EV. (2009) Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate. Osteoporos Int. 20(12):2055-61 Abstract
Kanis JA, Johansson H, Oden A, McCloskey EV. (2009) Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX. Bone. 44(6):1049-54. Abstract
Yang L, Peel N, Clowes JA, McCloskey EV, Eastell R. (2009) Use of DXA-based structural engineering models of the proximal femur to discriminate hip fracture. J Bone Miner Res. 24(1):33-42 Abstract
McCloskey EV, Vasireddy S, Threlkeld J, Eastaugh J, Parry A, Bonnet N, Beneton M, Kanis JA, Charlesworth D. (2008) Vertebral fracture assessment (VFA) with a densitometer predicts future fractures in elderly women unselected for osteoporosis. J Bone Miner Res. 23(10):1561-8 Abstract
